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Correlation network analysis shows divergent effects of a long-term, high-fat diet and exercise on early stage osteoarthritis phenotypes in mice

BACKGROUND: Obesity increases knee osteoarthritis (OA) risk through metabolic, inflammatory, and biomechanical factors, but how these systemic and local mediators interact to drive OA pathology is not well understood. We tested the effect of voluntary running exercise after chronic diet-induced obes...

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Detalles Bibliográficos
Autores principales: Griffin, Timothy M., Batushansky, Albert, Hudson, Joanna, Lopes, Erika Barboza Prado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031811/
https://www.ncbi.nlm.nih.gov/pubmed/32099720
http://dx.doi.org/10.1016/j.jshs.2019.05.008