Cargando…

Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production

BACKGROUND: Osteoporosis is a worldwide severe bone disease. This study aimed to evaluate the effect of polyphyllin VII on the genesis of osteoclasts from bone marrow macrophages (BMMs) and its potentiality as a therapeutic drug for osteoporosis. METHODS: BMMs were induced to differentiate into oste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Long, Song, Hanyi, Zhang, Yiqi, Ren, Zhaozhou, Li, Minghe, Fu, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031869/ https://www.ncbi.nlm.nih.gov/pubmed/32075617 http://dx.doi.org/10.1186/s12891-020-3077-z

Ejemplares similares

Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
por: Zhang, Chao, et al.
Publicado: (2016)

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer
por: He, Dong-Xu, et al.
Publicado: (2015)

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer
por: Song, Cheng, et al.
Publicado: (2021)

Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
por: Zhang, Chao, et al.
Publicado: (2016)

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo
por: Zhang, Chao, et al.
Publicado: (2021)

Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF-κB pathways in A549 human lung cancer cells
por: He, Hao, et al.
Publicado: (2020)

Flavopiridol Protects Bone Tissue by Attenuating RANKL Induced Osteoclast Formation
por: Hu, Zi’ang, et al.
Publicado: (2018)

TRAF Family Member-Associated NF-κB Activator (TANK) Induced by RANKL Negatively Regulates Osteoclasts Survival and Function
por: Wu, Mengrui, et al.
Publicado: (2012)

Polyphyllin VII induces CTC anoikis to inhibit lung cancer metastasis through EGFR pathway regulation
por: Que, Zujun, et al.
Publicado: (2023)

SRC-3/TRAF4 facilitates ovarian cancer development by activating the PI3K/AKT signaling pathway
por: Wang, Ying, et al.
Publicado: (2023)

The Effects of Aronia melanocarpa ‘Viking’ Extracts in Attenuating RANKL-Induced Osteoclastic Differentiation by Inhibiting ROS Generation and c-FOS/NFATc1 Signaling
por: Ghosh, Mithun, et al.
Publicado: (2018)

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
por: Long, Jianwen, et al.
Publicado: (2020)

Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity
por: He, Jianbo, et al.
Publicado: (2021)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
por: Ahmad, Bashir, et al.
Publicado: (2021)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling‐mediated TRAF6 and c‐Src recruitment and NF‐κB, MAPK and Akt pathways
por: Chen, Huiwen, et al.
Publicado: (2020)

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways
por: Yuan, Yu, et al.
Publicado: (2020)

Signaling crosstalk between RANKL and interferons in osteoclast differentiation
por: Takayanagi, Hiroshi, et al.
Publicado: (2002)

Berberine Sulfate Attenuates Osteoclast Differentiation through RANKL Induced NF-κB and NFAT Pathways
por: Zhou, Lin, et al.
Publicado: (2015)

Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer
por: Zhao, Liubiqi, et al.
Publicado: (2021)

Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer
por: Yu, Jinglu, et al.
Publicado: (2020)

Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis
por: Kim, Nacksung, et al.
Publicado: (2005)

Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption
por: Boyce, Brendan F., et al.
Publicado: (2018)

RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro
por: Sutherland, Karen A, et al.
Publicado: (2009)

Clathrin-dependent endocytosis of membrane-bound RANKL in differentiated osteoclasts
por: Narducci, P., et al.
Publicado: (2010)

Serum amyloid A inhibits RANKL-induced osteoclast formation
por: Oh, Eunseo, et al.
Publicado: (2015)

Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression
por: Hwang, Youn-Hwan, et al.
Publicado: (2018)

The effects of vasoactive intestinal peptide on RANKL-induced osteoclast formation
por: Qu, Hongyi, et al.
Publicado: (2021)

Water extract of Uncaria sinensis suppresses RANKL-induced bone loss by attenuating osteoclast differentiation and bone resorption
por: Ha, Hyunil, et al.
Publicado: (2017)

Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells
por: Cheng, Guang, et al.
Publicado: (2021)

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages
por: Mota, Ryerson Fonseca, et al.
Publicado: (2022)

Attenuation of the Na/K-ATPase/Src/ROS amplification signaling pathway by astaxanthin ameliorates myocardial cell oxidative stress injury
por: Qu, Xuefeng, et al.
Publicado: (2020)

CYT387, a JAK-Specific Inhibitor Impedes Osteoclast Activity and Oophorectomy-Induced Osteoporosis via Modulating RANKL and ROS Signaling Pathways
por: Li, Jing, et al.
Publicado: (2022)

The calcium channel TRPV6 is a novel regulator of RANKL‐induced osteoclastic differentiation and bone absorption activity through the IGF–PI3K–AKT pathway
por: Ma, Jun, et al.
Publicado: (2020)

Carboxypeptidase E Is a Novel Modulator of RANKL-Induced Osteoclast Differentiation
por: Kim, Hyun-Ju, et al.
Publicado: (2014)

Selective Regulation of MAPK Signaling Mediates RANKL-dependent Osteoclast Differentiation
por: Lee, Kyunghee, et al.
Publicado: (2016)

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
por: Kim, Kabsun, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_r76dnkuf1jnducp45kgm9kq8h3