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A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

BACKGROUND: Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized b...

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Detalles Bibliográficos
Autores principales: Espeso-Gil, Sergio, Halene, Tobias, Bendl, Jaroslav, Kassim, Bibi, Ben Hutta, Gabriella, Iskhakova, Marina, Shokrian, Neda, Auluck, Pavan, Javidfar, Behnam, Rajarajan, Prashanth, Chandrasekaran, Sandhya, Peter, Cyril J., Cote, Alanna, Birnbaum, Rebecca, Liao, Will, Borrman, Tyler, Wiseman, Jennifer, Bell, Aaron, Bannon, Michael J., Roussos, Panagiotis, Crary, John F., Weng, Zhiping, Marenco, Stefano, Lipska, Barbara, Tsankova, Nadejda M., Huckins, Laura, Jiang, Yan, Akbarian, Schahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031924/
https://www.ncbi.nlm.nih.gov/pubmed/32075678
http://dx.doi.org/10.1186/s13073-020-0715-x