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Combretastatin A4/poly(L-glutamic acid)-graft-PEG conjugates self-assembled to nanoparticles
Combretastatin A4 (CA4) possesses varying ability to cause vascular disruption in tumors, while the short half-life, low water solubility and deactivation of many CA4 analogs during storage limited its antitumor efficacy and drug stability. A novel macromolecular conjugate of CA4 (CA4-PL) was synthe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032092/ https://www.ncbi.nlm.nih.gov/pubmed/32104392 http://dx.doi.org/10.1016/j.ajps.2017.10.001 |