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Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation...

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Detalles Bibliográficos
Autores principales: Raja, Maria Abdul Ghafoor, Katas, Haliza, Amjad, Muhammad Wahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032099/
https://www.ncbi.nlm.nih.gov/pubmed/32104477
http://dx.doi.org/10.1016/j.ajps.2018.12.005