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Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA
Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Shenyang Pharmaceutical University
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032099/ https://www.ncbi.nlm.nih.gov/pubmed/32104477 http://dx.doi.org/10.1016/j.ajps.2018.12.005 |