Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment

Novel oral microbeads were developed based on a biopolymer–drug conjugate of doxorubicin (DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al(3+), Ca(2+) and Zn(2+). The results showed that using zinc acet...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheewatanakornkool, Kamonrak, Niratisai, Sathit, Manchun, Somkamol, Dass, Crispin R., Sriamornsak, Pornsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032137/
https://www.ncbi.nlm.nih.gov/pubmed/32104364
http://dx.doi.org/10.1016/j.ajps.2017.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032137/
https://www.ncbi.nlm.nih.gov/pubmed/32104364
http://dx.doi.org/10.1016/j.ajps.2017.07.005

Ejemplares similares