Synthesis, characterization and in vivo evaluation of honokiol bisphosphate prodrugs protects against rats’ brain ischemia-reperfusion injury

Honokiol (HK) usage is greatly restricted by its poor aqueous solubility and limited oral bioavailability. We synthesized and characterized a novel phosphate prodrug of honokiol (HKP) for in vitro and in vivo use. HKP greatly enhanced the aqueous solubility of HK (127.54 ± 15.53 mg/ml) and the stabi...

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Detalles Bibliográficos
Autores principales: Xu, Gaojie, Dong, Renghan, Liu, Jin, Zhao, Li, Zeng, Yan, Xiao, Xiaofan, An, Jinglin, Huang, Sheng, Zhong, Yueling, Guang, Bing, Yang, Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032162/
https://www.ncbi.nlm.nih.gov/pubmed/32104490
http://dx.doi.org/10.1016/j.ajps.2018.11.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032162/
https://www.ncbi.nlm.nih.gov/pubmed/32104490
http://dx.doi.org/10.1016/j.ajps.2018.11.004

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