Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method

The objective of this work is to construct a nanosuspension drug delivery system of probucol, a BCS II drug, in order to improve its dissolution and oral bioavailability. The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticl...

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Detalles Bibliográficos
Autores principales: Li, Fang, Li, Linsen, Wang, Shaoning, Yang, Yan, Li, Jia, Liu, Dongchun, Zhang, Sijie, Wang, Siling, Xu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032176/
https://www.ncbi.nlm.nih.gov/pubmed/32104491
http://dx.doi.org/10.1016/j.ajps.2018.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032176/
https://www.ncbi.nlm.nih.gov/pubmed/32104491
http://dx.doi.org/10.1016/j.ajps.2018.12.001

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