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Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method
The objective of this work is to construct a nanosuspension drug delivery system of probucol, a BCS II drug, in order to improve its dissolution and oral bioavailability. The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticl...
Autores principales: | Li, Fang, Li, Linsen, Wang, Shaoning, Yang, Yan, Li, Jia, Liu, Dongchun, Zhang, Sijie, Wang, Siling, Xu, Hui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032176/ https://www.ncbi.nlm.nih.gov/pubmed/32104491 http://dx.doi.org/10.1016/j.ajps.2018.12.001 |
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