PEPT1-mediated prodrug strategy for oral delivery of peramivir

Peramivir was a novel and highly potent neuraminidase (NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability (only 3%) due to the high polarity (log P of −1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated...

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Detalles Bibliográficos
Autores principales: Sun, Yongbing, Gan, Wei, Lei, Mingdao, Jiang, Wei, Cheng, Meng, He, Junwei, Sun, Qi, Liu, Wan, Hu, Lvjiang, Jin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032255/
https://www.ncbi.nlm.nih.gov/pubmed/32104429
http://dx.doi.org/10.1016/j.ajps.2018.05.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032255/
https://www.ncbi.nlm.nih.gov/pubmed/32104429
http://dx.doi.org/10.1016/j.ajps.2018.05.008

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