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Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches

Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of water-insoluble drugs. However, the aggregation mechanism of drug-cyclodextrin complexes is still unclear. This research aimed to investigate the molecular aggregation mechanism of glipizide/cyclodextrin complexation by th...

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Detalles Bibliográficos
Autores principales: Huang, Tianhe, Zhao, Qianqian, Su, Yan, Ouyang, Defang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032256/
https://www.ncbi.nlm.nih.gov/pubmed/32104487
http://dx.doi.org/10.1016/j.ajps.2018.10.008