The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation

The iron–sulfur (FeS) cluster helicase DDX11 is associated with a human disorder termed Warsaw Breakage Syndrome. Interestingly, one disease-associated mutation affects the highly conserved arginine-263 in the FeS cluster-binding motif. Here, we demonstrate that the FeS cluster in DDX11 is required...

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Detalles Bibliográficos
Autores principales: Simon, Anna K, Kummer, Sandra, Wild, Sebastian, Lezaja, Aleksandra, Teloni, Federico, Jozwiakowski, Stanislaw K, Altmeyer, Matthias, Gari, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032568/
https://www.ncbi.nlm.nih.gov/pubmed/32071282
http://dx.doi.org/10.26508/lsa.201900547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032568/
https://www.ncbi.nlm.nih.gov/pubmed/32071282
http://dx.doi.org/10.26508/lsa.201900547

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