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The iron–sulfur helicase DDX11 promotes the generation of single-stranded DNA for CHK1 activation
The iron–sulfur (FeS) cluster helicase DDX11 is associated with a human disorder termed Warsaw Breakage Syndrome. Interestingly, one disease-associated mutation affects the highly conserved arginine-263 in the FeS cluster-binding motif. Here, we demonstrate that the FeS cluster in DDX11 is required...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Life Science Alliance LLC
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032568/ https://www.ncbi.nlm.nih.gov/pubmed/32071282 http://dx.doi.org/10.26508/lsa.201900547 |