Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells

Lymphangioleiomyomatosis (LAM) is a devastating lung disease caused by inactivating gene mutations in either TSC1 or TSC2 that result in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1). As LAM occurs predominantly in women during their reproductive age and is exacerbated by...

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Detalles Bibliográficos
Autores principales: Lu, Yiyang, Liu, Xiaolei, Zhang, Erik, Kopras, Elizabeth J., Smith, Eric P., Astreinidis, Aristotelis, Li, Chenggang, Leung, Yuet-Kin, Ho, Shuk-Mei, Yu, Jane J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032738/
https://www.ncbi.nlm.nih.gov/pubmed/32078667
http://dx.doi.org/10.1371/journal.pone.0228894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032738/
https://www.ncbi.nlm.nih.gov/pubmed/32078667
http://dx.doi.org/10.1371/journal.pone.0228894

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