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Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans

Exposure to environmental stress is clinically established to influence male reproductive health, but the impact of normal cellular metabolism on sperm quality is less well-defined. Here we show that impaired mitochondrial proline catabolism, reduces energy-storing flavin adenine dinucleotide (FAD)...

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Detalles Bibliográficos
Autores principales: Yen, Chia-An, Ruter, Dana L, Turner, Christian D, Pang, Shanshan, Curran, Sean P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032928/
https://www.ncbi.nlm.nih.gov/pubmed/32022684
http://dx.doi.org/10.7554/eLife.52899