Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy

Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-thermodynamic stability to solubilize and load paclitaxel for targeted cancer therapy. Each RNA nanoparticle covalently loads...

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Detalles Bibliográficos
Autores principales: Guo, Sijin, Vieweger, Mario, Zhang, Kaiming, Yin, Hongran, Wang, Hongzhi, Li, Xin, Li, Shanshan, Hu, Shuiying, Sparreboom, Alex, Evers, B. Mark, Dong, Yizhou, Chiu, Wah, Guo, Peixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033104/
https://www.ncbi.nlm.nih.gov/pubmed/32080195
http://dx.doi.org/10.1038/s41467-020-14780-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033104/
https://www.ncbi.nlm.nih.gov/pubmed/32080195
http://dx.doi.org/10.1038/s41467-020-14780-5

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