Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway

Indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 2 (IDO2), and tryptophan 2,3-dioxygenase (TDO) initiate the first step of the kynurenine pathway (KP), leading to the transformation of l-tryptophan (Trp) into l-kynurenine (Kyn) and other downstream metabolites. Kyn is known as an en...

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Detalles Bibliográficos
Autores principales: Du, Lisha, Xing, Zikang, Tao, Bangbao, Li, Tianqi, Yang, Dan, Li, Weirui, Zheng, Yuanting, Kuang, Chunxiang, Yang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033114/
https://www.ncbi.nlm.nih.gov/pubmed/32296044
http://dx.doi.org/10.1038/s41392-019-0103-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033114/
https://www.ncbi.nlm.nih.gov/pubmed/32296044
http://dx.doi.org/10.1038/s41392-019-0103-4

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