UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites

UV light is a widely-employed, and environmentally-sensitive bactericide but its mechanism of action is not fully defined. Proteins are major chromophores and targets for damage due to their abundance, but the role of proteins in inducing damage to bound DNA, and the effects on DNA-protein interacti...

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Detalles Bibliográficos
Autores principales: Leinisch, Fabian, Mariotti, Michele, Andersen, Sofie Hagel, Lindemose, Søren, Hägglund, Per, Møllegaard, Niels Erik, Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033146/
https://www.ncbi.nlm.nih.gov/pubmed/32080294
http://dx.doi.org/10.1038/s41598-020-59855-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033146/
https://www.ncbi.nlm.nih.gov/pubmed/32080294
http://dx.doi.org/10.1038/s41598-020-59855-x

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