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UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites
UV light is a widely-employed, and environmentally-sensitive bactericide but its mechanism of action is not fully defined. Proteins are major chromophores and targets for damage due to their abundance, but the role of proteins in inducing damage to bound DNA, and the effects on DNA-protein interacti...
Autores principales: | Leinisch, Fabian, Mariotti, Michele, Andersen, Sofie Hagel, Lindemose, Søren, Hägglund, Per, Møllegaard, Niels Erik, Davies, Michael J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033146/ https://www.ncbi.nlm.nih.gov/pubmed/32080294 http://dx.doi.org/10.1038/s41598-020-59855-x |
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