Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

Although peptide chemistry has made great progress, the frequent occurrence of aspartimide formation during peptide synthesis remains a formidable challenge. Aspartimide formation leads to low yields in addition to costly purification or even inaccessible peptide sequences. Here, we report an altern...

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Detalles Bibliográficos
Autores principales: Neumann, Kevin, Farnung, Jakob, Baldauf, Simon, Bode, Jeffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033154/
https://www.ncbi.nlm.nih.gov/pubmed/32080186
http://dx.doi.org/10.1038/s41467-020-14755-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033154/
https://www.ncbi.nlm.nih.gov/pubmed/32080186
http://dx.doi.org/10.1038/s41467-020-14755-6

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