Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells

Targeted protein degradation (TPD) through a proteasome-dependent pathway induced by heterofunctional small molecules is initiated by the formation of a ternary complex with recruited E3 ligases. This complex formation affects the degradation ability of TPD molecules, and thus we tested for visualiz...

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Detalles Bibliográficos
Autores principales: Kaji, Tomohiro, Koga, Hiroshi, Kuroha, Mutsumi, Akimoto, Toshihiko, Hayata, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033280/
https://www.ncbi.nlm.nih.gov/pubmed/32080280
http://dx.doi.org/10.1038/s41598-020-59966-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033280/
https://www.ncbi.nlm.nih.gov/pubmed/32080280
http://dx.doi.org/10.1038/s41598-020-59966-5

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