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Technological advances and computational approaches for alternative splicing analysis in single cells

Alternative splicing of RNAs generates isoform diversity, resulting in different proteins that are necessary for maintaining cellular function and identity. The discovery of alternative splicing has been revolutionized by next-generation transcriptomic sequencing mainly using bulk RNA-sequencing, wh...

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Detalles Bibliográficos
Autores principales: Wen, Wei Xiong, Mead, Adam J., Thongjuea, Supat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033300/
https://www.ncbi.nlm.nih.gov/pubmed/32099593
http://dx.doi.org/10.1016/j.csbj.2020.01.009