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Pharmacodynamic principles and the time course of immediate drug effects
This tutorial defines the principles of the concentration - effect relationship which are the basis of pharmacodynamics. The two key parameters of pharmacodynamics are the maximum response (Emax) and the concentration producing 50% of Emax (C(50)). The time course of effect is illustrated under the...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Clinical Pharmacology and Therapeutics
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033401/ https://www.ncbi.nlm.nih.gov/pubmed/32095468 http://dx.doi.org/10.12793/tcp.2017.25.4.157 |
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author | Holford, Nick |
author_facet | Holford, Nick |
author_sort | Holford, Nick |
collection | PubMed |
description | This tutorial defines the principles of the concentration - effect relationship which are the basis of pharmacodynamics. The two key parameters of pharmacodynamics are the maximum response (Emax) and the concentration producing 50% of Emax (C(50)). The time course of effect is illustrated under the assumption that drug effects are immediately related to concentration in the central compartment e.g. plasma. The related idea of duration of drug action and its relationship to dose is shown to have a simple relationship with drug half-life. |
format | Online Article Text |
id | pubmed-7033401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Society for Clinical Pharmacology and Therapeutics |
record_format | MEDLINE/PubMed |
spelling | pubmed-70334012020-02-24 Pharmacodynamic principles and the time course of immediate drug effects Holford, Nick Transl Clin Pharmacol Tutorial This tutorial defines the principles of the concentration - effect relationship which are the basis of pharmacodynamics. The two key parameters of pharmacodynamics are the maximum response (Emax) and the concentration producing 50% of Emax (C(50)). The time course of effect is illustrated under the assumption that drug effects are immediately related to concentration in the central compartment e.g. plasma. The related idea of duration of drug action and its relationship to dose is shown to have a simple relationship with drug half-life. Korean Society for Clinical Pharmacology and Therapeutics 2017-12 2017-12-20 /pmc/articles/PMC7033401/ /pubmed/32095468 http://dx.doi.org/10.12793/tcp.2017.25.4.157 Text en Copyright © 2017 Translational and Clinical Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). |
spellingShingle | Tutorial Holford, Nick Pharmacodynamic principles and the time course of immediate drug effects |
title | Pharmacodynamic principles and the time course of immediate drug effects |
title_full | Pharmacodynamic principles and the time course of immediate drug effects |
title_fullStr | Pharmacodynamic principles and the time course of immediate drug effects |
title_full_unstemmed | Pharmacodynamic principles and the time course of immediate drug effects |
title_short | Pharmacodynamic principles and the time course of immediate drug effects |
title_sort | pharmacodynamic principles and the time course of immediate drug effects |
topic | Tutorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033401/ https://www.ncbi.nlm.nih.gov/pubmed/32095468 http://dx.doi.org/10.12793/tcp.2017.25.4.157 |
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