6mer Seed Toxicity in Viral microRNAs

MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is highly toxi...

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Detalles Bibliográficos
Autores principales: Murmann, Andrea E., Bartom, Elizabeth T., Schipma, Matthew J., Vilker, Jacob, Chen, Siquan, Peter, Marcus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033618/
https://www.ncbi.nlm.nih.gov/pubmed/31838022
http://dx.doi.org/10.1016/j.isci.2019.11.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033618/
https://www.ncbi.nlm.nih.gov/pubmed/31838022
http://dx.doi.org/10.1016/j.isci.2019.11.031

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