Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines

Neuroblastoma (NB) is the most common pediatric malignant extracranial solid tumor. Despite multi-modality therapies, the emergence of drug resistance is an obstacle in the treatment of high-risk NB patients (with MYCN amplification). In our previous study, we found that rapamycin and MK-2206 synerg...

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Detalles Bibliográficos
Autores principales: Dong, Yudi, Gong, Wei, Hua, Zhongyan, Chen, Bo, Zhao, Guifeng, Liu, Zhihui, Thiele, Carol J., Li, Zhijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033642/
https://www.ncbi.nlm.nih.gov/pubmed/32116708
http://dx.doi.org/10.3389/fphar.2020.00031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033642/
https://www.ncbi.nlm.nih.gov/pubmed/32116708
http://dx.doi.org/10.3389/fphar.2020.00031

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