Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors

Inhibitory action of newly synthesised 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides compounds 2–13 against human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII, was evaluated. hCA I was efficiently inhibited by compounds 2–13 with inhibition cons...

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Detalles Bibliográficos
Autores principales: El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., Ahmed, Hany E. A., Bua, Sivia, Nocentini, Alessio, AlSaif, Nawaf A., Obaidullah, Ahmad J., Hefnawy, Mohamed M., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034075/
https://www.ncbi.nlm.nih.gov/pubmed/32009479
http://dx.doi.org/10.1080/14756366.2020.1722121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034075/
https://www.ncbi.nlm.nih.gov/pubmed/32009479
http://dx.doi.org/10.1080/14756366.2020.1722121

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