The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

Store-operated Orai1 channels regulate a wide range of cellular functions from gene expression to cell proliferation. Previous studies have shown that gating of Orai1 channels is regulated by the outer pore residues V102 and F99, which together function as a hydrophobic gate to block ion conduction...

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Detalles Bibliográficos
Autores principales: Yamashita, Megumi, Ing, Christopher E., Yeung, Priscilla See-Wai, Maneshi, Mohammad M., Pomès, Régis, Prakriya, Murali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034092/
https://www.ncbi.nlm.nih.gov/pubmed/31816637
http://dx.doi.org/10.1085/jgp.201912397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034092/
https://www.ncbi.nlm.nih.gov/pubmed/31816637
http://dx.doi.org/10.1085/jgp.201912397

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