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The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate
Store-operated Orai1 channels regulate a wide range of cellular functions from gene expression to cell proliferation. Previous studies have shown that gating of Orai1 channels is regulated by the outer pore residues V102 and F99, which together function as a hydrophobic gate to block ion conduction...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034092/ https://www.ncbi.nlm.nih.gov/pubmed/31816637 http://dx.doi.org/10.1085/jgp.201912397 |