Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects. Sustained release THCl nanosponges hydrogel was fabricated to deliver the drug topically. Pure THCl (d...

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Detalles Bibliográficos
Autores principales: Amer, Reham I., El-Osaily, Ghada H., Gad, Sameh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034181/
https://www.ncbi.nlm.nih.gov/pubmed/32154153
http://dx.doi.org/10.4103/japtr.JAPTR_85_19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034181/
https://www.ncbi.nlm.nih.gov/pubmed/32154153
http://dx.doi.org/10.4103/japtr.JAPTR_85_19

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