Synthesis of 4-(2-fluorophenyl)-7-methoxycoumarin: experimental and computational evidence for intramolecular and intermolecular C–F···H–C bonds

4-(2-Fluorophenyl)-7-methoxycoumarin (6) was synthesized by Pechmann reaction under mild conditions via a three-step reaction. The solution-state (1)H NMR spectra of 6 showed a strong intramolecular interaction between F and H5 (J(FH) = 2.6 Hz) and (13)C NMR suggested that this C–F···H–C coupling is...

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Detalles Bibliográficos
Autores principales: Mzozoyana, Vuyisa, van Heerden, Fanie R, Grimmer, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034221/
https://www.ncbi.nlm.nih.gov/pubmed/32117476
http://dx.doi.org/10.3762/bjoc.16.22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034221/
https://www.ncbi.nlm.nih.gov/pubmed/32117476
http://dx.doi.org/10.3762/bjoc.16.22

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