Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing candidates before clinical study. However, no comput...

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Detalles Bibliográficos
Autores principales: Shin, Hyun Kil, Kang, Myung-Gyun, Park, Daeui, Park, Tamina, Yoon, Seokjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034408/
https://www.ncbi.nlm.nih.gov/pubmed/32116729
http://dx.doi.org/10.3389/fphar.2020.00067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034408/
https://www.ncbi.nlm.nih.gov/pubmed/32116729
http://dx.doi.org/10.3389/fphar.2020.00067

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