Noninvasive quantification of SIRT1 expression–activity and pharmacologic inhibition in a rat model of intracerebral glioma using 2-[(18)F]BzAHA PET/CT/MRI

BACKGROUND: Several studies demonstrated that glioblastoma multiforme progression and recurrence is linked to epigenetic regulatory mechanisms. Sirtuin 1 (SIRT1) plays an important role in glioma progression, invasion, and treatment response and is a potential therapeutic target. The aim of this stu...

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Detalles Bibliográficos
Autores principales: Laws, Maxwell T, Bonomi, Robin E, Gelovani, David J, Llaniguez, Jeremy, Lu, Xin, Mangner, Thomas, Gelovani, Juri G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034639/
https://www.ncbi.nlm.nih.gov/pubmed/32118205
http://dx.doi.org/10.1093/noajnl/vdaa006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034639/
https://www.ncbi.nlm.nih.gov/pubmed/32118205
http://dx.doi.org/10.1093/noajnl/vdaa006

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