Systematic analysis of the binding behaviour of UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads

The multi-domain protein UHRF1 is essential for DNA methylation maintenance and binds DNA via a base-flipping mechanism with a preference for hemi-methylated CpG sites. We investigated its binding to hemi- and symmetrically modified DNA containing either 5-methylcytosine (mC), 5-hydroxymethylcytosin...

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Detalles Bibliográficos
Autores principales: Schneider, Markus, Trummer, Carina, Stengl, Andreas, Zhang, Peng, Szwagierczak, Aleksandra, Cardoso, M. Cristina, Leonhardt, Heinrich, Bauer, Christina, Antes, Iris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034832/
https://www.ncbi.nlm.nih.gov/pubmed/32084194
http://dx.doi.org/10.1371/journal.pone.0229144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034832/
https://www.ncbi.nlm.nih.gov/pubmed/32084194
http://dx.doi.org/10.1371/journal.pone.0229144

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