Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

LAT molecules defective in ubiquitination have an increased half-life and induce enhanced signaling when expressed in T cells. In this study, we have examined the role of ubiquitination in regulating LAT endocytosis, recycling, and degradation in resting and stimulated T cells. By tracking and compa...

Descripción completa

Detalles Bibliográficos
Autores principales: Balagopalan, Lakshmi, Malik, Hiba, McIntire, Katherine M., Garvey, Joseph A., Nguyen, Tiffany, Rodriguez-Peña, Ana B., Samelson, Lawrence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034843/
https://www.ncbi.nlm.nih.gov/pubmed/32084172
http://dx.doi.org/10.1371/journal.pone.0229036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034843/
https://www.ncbi.nlm.nih.gov/pubmed/32084172
http://dx.doi.org/10.1371/journal.pone.0229036

Ejemplares similares