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Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells
LAT molecules defective in ubiquitination have an increased half-life and induce enhanced signaling when expressed in T cells. In this study, we have examined the role of ubiquitination in regulating LAT endocytosis, recycling, and degradation in resting and stimulated T cells. By tracking and compa...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034843/ https://www.ncbi.nlm.nih.gov/pubmed/32084172 http://dx.doi.org/10.1371/journal.pone.0229036 |