The structural basis for cohesin-CTCF anchored loops

Cohesin catalyzes folding of the genome into loops that are anchored by CTCF(1). The molecular mechanism of how cohesin and CTCF structure the 3D genome has remained unclear. Here we show that a segment within the CTCF N-terminus interacts with the SA2-SCC1 subunits of cohesin. A 2.6Å crystal struct...

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Detalles Bibliográficos
Autores principales: Li, Yan, Haarhuis, Judith H.I., Cacciatore, Ángela Sedeño, Oldenkamp, Roel, van Ruiten, Marjon S., Willems, Laureen, Teunissen, Hans, Muir, Kyle W., de Wit, Elzo, Rowland, Benjamin D., Panne, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035113/
https://www.ncbi.nlm.nih.gov/pubmed/31905366
http://dx.doi.org/10.1038/s41586-019-1910-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035113/
https://www.ncbi.nlm.nih.gov/pubmed/31905366
http://dx.doi.org/10.1038/s41586-019-1910-z

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