Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (K(Na)1.1) Na(+)-activated K(+) channels

Gain-of-function mutations in KCNT1, the gene encoding Slack (K(Na)1.1) channels, result in epilepsy of infancy with migrating focal seizures (EIMFS) and several other forms of epilepsy associated with severe intellectual disability. We have generated a mouse model of this condition by replacing the...

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Detalles Bibliográficos
Autores principales: Quraishi, Imran H., Mercier, Michael R., McClure, Heather, Couture, Rachael L., Schwartz, Michael L., Lukowski, Robert, Ruth, Peter, Kaczmarek, Leonard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035262/
https://www.ncbi.nlm.nih.gov/pubmed/32081855
http://dx.doi.org/10.1038/s41598-020-60028-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035262/
https://www.ncbi.nlm.nih.gov/pubmed/32081855
http://dx.doi.org/10.1038/s41598-020-60028-z

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