A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity

Phosphorylation of Munc18-1 (Stxbp1), a presynaptic organizer of synaptic vesicle fusion, is a powerful mechanism to regulate synaptic strength. Munc18-1 is a proposed substrate for the Down Syndrome-related kinase dual-specificity tyrosine phosphorylation-regulate kinase 1a (Dyrk1a) and mutations i...

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Detalles Bibliográficos
Autores principales: Classen, Jessica, Saarloos, Ingrid, Meijer, Marieke, Sullivan, Patrick F., Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035266/
https://www.ncbi.nlm.nih.gov/pubmed/32081899
http://dx.doi.org/10.1038/s41598-020-59757-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035266/
https://www.ncbi.nlm.nih.gov/pubmed/32081899
http://dx.doi.org/10.1038/s41598-020-59757-y

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