X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na(+)/substrate-bound, inward-facing occluded conformation. To obta...

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Detalles Bibliográficos
Autores principales: Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Nissen, Poul, Gether, Ulrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035281/
https://www.ncbi.nlm.nih.gov/pubmed/32081981
http://dx.doi.org/10.1038/s41467-020-14735-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035281/
https://www.ncbi.nlm.nih.gov/pubmed/32081981
http://dx.doi.org/10.1038/s41467-020-14735-w

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