MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

The MEN1 gene, a tumor suppressor gene that encodes the protein menin, is mutated at high frequencies in neuroendocrine (NE) tumors; however, the biological importance of this gene in NE-type lung cancer in vivo remains unclear. Here, we established an ATII-specific Kras(G12D/+)/Men1(−/−) driven gen...

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Detalles Bibliográficos
Autores principales: Qiu, Huan, Jin, Bang-Ming, Wang, Zhan-Feng, Xu, Bin, Zheng, Qi-Fan, Zhang, Li, Zhu, Ling-Yu, Shi, Shuang, Yuan, Jun-Bo, Lin, Xiao, Gao, Shu-Bin, Jin, Guang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035285/
https://www.ncbi.nlm.nih.gov/pubmed/32081882
http://dx.doi.org/10.1038/s41467-020-14614-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035285/
https://www.ncbi.nlm.nih.gov/pubmed/32081882
http://dx.doi.org/10.1038/s41467-020-14614-4

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