Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization

Activating mutations of epidermal growth factor receptor (EGFR) play crucial roles in the oncogenesis of human non-small cell lung cancer (NSCLC). By screening 79 commercially available natural products, we found that the natural compound deguelin exhibited a profound anti-tumor effect on NSCLC via...

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Detalles Bibliográficos
Autores principales: Gao, Feng, Yu, Xinfang, Li, Ming, Zhou, Li, Liu, Wenbin, Li, Wei, Liu, Haidan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035355/
https://www.ncbi.nlm.nih.gov/pubmed/32081857
http://dx.doi.org/10.1038/s41419-020-2344-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035355/
https://www.ncbi.nlm.nih.gov/pubmed/32081857
http://dx.doi.org/10.1038/s41419-020-2344-0

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