Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to...

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Detalles Bibliográficos
Autores principales: Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035387/
https://www.ncbi.nlm.nih.gov/pubmed/32081875
http://dx.doi.org/10.1038/s41467-020-14452-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035387/
https://www.ncbi.nlm.nih.gov/pubmed/32081875
http://dx.doi.org/10.1038/s41467-020-14452-4

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