Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in identifying alternative pathways to the traits under investigation. Here, we develop MR-TRYX, a framework that exploits horizontal pleiotropy to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035387/ https://www.ncbi.nlm.nih.gov/pubmed/32081875 http://dx.doi.org/10.1038/s41467-020-14452-4 |