Slowly Repaired Bulky DNA Damages Modulate Cellular Redox Environment Leading to Premature Senescence

Treatments on neoplastic diseases and cancer using genotoxic drugs often cause long-term health problems related to premature aging. The underlying mechanism is poorly understood. Based on the study of a long-lasting senescence-like growth arrest (10-12 weeks) of human dermal fibroblasts induced by...

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Detalles Bibliográficos
Autores principales: Zhang, Yujie, Guo, Peiyan, Xiang, Wanchen, Liu, Qingxi, Liu, Xinyi, Ma, Ning, Zhou, Sa, He, Hongpeng, Wlaschek, Meinhard, Scharffetter-Kochanek, Karin, Zhang, Tong-Cun, Ma, Wenjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035574/
https://www.ncbi.nlm.nih.gov/pubmed/32104534
http://dx.doi.org/10.1155/2020/5367102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035574/
https://www.ncbi.nlm.nih.gov/pubmed/32104534
http://dx.doi.org/10.1155/2020/5367102

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