Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release

Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca(2+) release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca(2+) activation mechanism has been well-characterized, how Syt1 clamps trans...

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Detalles Bibliográficos
Autores principales: Tagliatti, Erica, Bello, Oscar D., Mendonça, Philipe R. F., Kotzadimitriou, Dimitrios, Nicholson, Elizabeth, Coleman, Jeff, Timofeeva, Yulia, Rothman, James E., Krishnakumar, Shyam S., Volynski, Kirill E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035618/
https://www.ncbi.nlm.nih.gov/pubmed/32015138
http://dx.doi.org/10.1073/pnas.1920403117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035618/
https://www.ncbi.nlm.nih.gov/pubmed/32015138
http://dx.doi.org/10.1073/pnas.1920403117

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