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Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca(2+) release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca(2+) activation mechanism has been well-characterized, how Syt1 clamps trans...
Autores principales: | Tagliatti, Erica, Bello, Oscar D., Mendonça, Philipe R. F., Kotzadimitriou, Dimitrios, Nicholson, Elizabeth, Coleman, Jeff, Timofeeva, Yulia, Rothman, James E., Krishnakumar, Shyam S., Volynski, Kirill E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035618/ https://www.ncbi.nlm.nih.gov/pubmed/32015138 http://dx.doi.org/10.1073/pnas.1920403117 |
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