Allosteric mechanism for site-specific ubiquitination of FANCD2

DNA damage repair is implemented by proteins that are coordinated by specialised molecular signals. One such signal in the Fanconi Anemia (FA) DNA-interstrand crosslink repair pathway is the site-specific monoubiquitination of FANCD2 and FANCI. The signal is mediated by a multi-protein FA core compl...

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Detalles Bibliográficos
Autores principales: Chaugule, Viduth K., Arkinson, Connor, Rennie, Martin L., Kämäräinen, Outi, Toth, Rachel, Walden, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035956/
https://www.ncbi.nlm.nih.gov/pubmed/31873223
http://dx.doi.org/10.1038/s41589-019-0426-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035956/
https://www.ncbi.nlm.nih.gov/pubmed/31873223
http://dx.doi.org/10.1038/s41589-019-0426-z

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