Guided nuclear exploration increases CTCF target search efficiency

The enormous size of mammalian genomes means that for a DNA-binding protein, the number of non-specific, off-target sites vastly exceeds the number of specific, cognate sites. How mammalian DNA-binding proteins overcome this challenge to efficiently locate their target sites is not known. Here throu...

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Detalles Bibliográficos
Autores principales: Hansen, Anders S., Amitai, Assaf, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036004/
https://www.ncbi.nlm.nih.gov/pubmed/31792445
http://dx.doi.org/10.1038/s41589-019-0422-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036004/
https://www.ncbi.nlm.nih.gov/pubmed/31792445
http://dx.doi.org/10.1038/s41589-019-0422-3

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