Dynamics of the context-specific translation arrest by chloramphenicol and linezolid

Chloramphenicol (CHL) and linezolid (LZD) are antibiotics that inhibit translation. Both were thought to block peptide bond formation between all combinations of amino acids. Yet recently, a strong nascent peptide context-dependency of CHL- and LZD-induced translation arrest was discovered. Here, we...

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Detalles Bibliográficos
Autores principales: Choi, Junhong, Marks, James, Zhang, Jingji, Chen, Dong-Hua, Wang, Jinfan, Vázquez-Laslop, Nora, Mankin, Alexander S., Puglisi, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036023/
https://www.ncbi.nlm.nih.gov/pubmed/31844301
http://dx.doi.org/10.1038/s41589-019-0423-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036023/
https://www.ncbi.nlm.nih.gov/pubmed/31844301
http://dx.doi.org/10.1038/s41589-019-0423-2

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