Cargando…

Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior

BACKGROUND: Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS: Eighty 10-week-ol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hui, Ding, Xiang, Terkeltaub, Robert, Lin, Hang, Zhang, Yuqing, Zhou, Bin, He, Ke, Li, Kun, Liu, Zhichen, Wei, Jie, Yang, Yuanheng, Xie, Hui, Zeng, Chao, Lei, Guanghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036179/ https://www.ncbi.nlm.nih.gov/pubmed/32087740 http://dx.doi.org/10.1186/s13075-020-2129-y

Ejemplares similares

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of In Vivo Studies
por: Jin, Hongyu, et al.
Publicado: (2023)

Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in Osteoarthritis Rats
por: Gao, Hui, et al.
Publicado: (2020)

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
por: D'Amico, Davide, et al.
Publicado: (2022)

The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity
por: Li, Yusheng, et al.
Publicado: (2016)

Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
por: Jiang, Jieyun, et al.
Publicado: (2023)

Cartilage Degeneration and Alignment in Severe Varus Knee Osteoarthritis
por: Nakagawa, Yasuaki, et al.
Publicado: (2015)

New insights into the interplay between autophagy and cartilage degeneration in osteoarthritis
por: Lv, Xiaoman, et al.
Publicado: (2022)

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration
por: Cao, Kun, et al.
Publicado: (2014)

Trimanganese Tetroxide Nanozyme protects Cartilage against Degeneration by Reducing Oxidative Stress in Osteoarthritis
por: Wang, Wenhan, et al.
Publicado: (2023)

Acupuncture Delays Cartilage Degeneration through Upregulating SIRT1 Expression in Rats with Osteoarthritis
por: Liu, Hui, et al.
Publicado: (2021)

Ursodeoxycholic Acid Ameliorates Pain Severity and Cartilage Degeneration in Monosodium Iodoacetate-Induced Osteoarthritis in Rats
por: Moon, Su-Jin, et al.
Publicado: (2014)

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis
por: Ji, Quanbo, et al.
Publicado: (2019)

Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis
por: Schulze-Tanzil, Gundula
Publicado: (2019)

Role of Syndecan-4 in the Inhibition of Articular Cartilage Degeneration in Osteoarthritis
por: Hattori, Yoshio, et al.
Publicado: (2023)

The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity
por: Li, Yusheng, et al.
Publicado: (2016)

Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA)
por: Yudoh, Kazuo, et al.
Publicado: (2010)

Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis
por: Zhang, Jinling, et al.
Publicado: (2018)

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2019)

Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat
por: TenBroek, Erica M., et al.
Publicado: (2016)

Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage—An In Vitro Study
por: Kuang, Biao, et al.
Publicado: (2019)

T140 blocks the SDF-1/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model
por: Wang, Kun, et al.
Publicado: (2017)

Nutrition and degeneration of articular cartilage
por: Wang, Yuze, et al.
Publicado: (2012)

NG2/CSPG4 regulates cartilage degeneration during TMJ osteoarthritis
por: Reed, David A., et al.
Publicado: (2022)

The role of AGEs in pathogenesis of cartilage destruction in osteoarthritis
por: He, Chao-Peng, et al.
Publicado: (2022)

Rehmannia alcohol extract inhibits neuropeptide secretion and alleviates osteoarthritis pain through cartilage protection
por: Huang, Yanfeng, et al.
Publicado: (2023)

Procyanidin B3 Prevents Articular Cartilage Degeneration and Heterotopic Cartilage Formation in a Mouse Surgical Osteoarthritis Model
por: Aini, Hailati, et al.
Publicado: (2012)

Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4
por: Cao, Chenxi, et al.
Publicado: (2022)

Recent Advances in Understanding the Role of Cartilage Lubrication in Osteoarthritis
por: Li, Yumei, et al.
Publicado: (2021)

Periodic knee injections of collagen tripeptide delay cartilage degeneration in rabbit experimental osteoarthritis
por: Naraoka, Takuya, et al.
Publicado: (2013)

JUNB‐FBXO21‐ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy
por: Lin, Zhiming, et al.
Publicado: (2021)

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis
por: Ebata, Taku, et al.
Publicado: (2021)

Osteoarthritis-Related Degeneration Alters the Biomechanical Properties of Human Menisci Before the Articular Cartilage
por: Seitz, Andreas M., et al.
Publicado: (2021)

Effect of Suppression of Rotational Joint Instability on Cartilage and Meniscus Degeneration in Mouse Osteoarthritis Model
por: Arakawa, Kohei, et al.
Publicado: (2022)

Mild treadmill exercise inhibits cartilage degeneration via macrophages in an osteoarthritis mouse model
por: Oka, Yuichiro, et al.
Publicado: (2023)

Changes in the Subchondral Bone, Visfatin, and Cartilage Biomarkers after Pharmacological Treatment of Experimental Osteoarthritis with Metformin and Alendronate
por: Lambova, Sevdalina Nikolova, et al.
Publicado: (2023)

Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level
por: Liu, Heng, et al.
Publicado: (2019)

AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis
por: Yi, Dan, et al.
Publicado: (2021)

Pain relief and cartilage repair by Nanofat against osteoarthritis: preclinical and clinical evidence
por: Chen, Zuxiang, et al.
Publicado: (2021)

CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis
por: Li, Bin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fi4dqjf38a2718k87sk94r73el